生物
交易激励
缺氧(环境)
细胞生物学
缺氧诱导因子1
Gα亚单位
信号转导
一氧化氮
缺氧诱导因子
激活剂(遗传学)
蛋白质亚单位
转录因子
泛素
芳香烃受体核转运体
活性氧
氧气
生物化学
基因
内分泌学
化学
有机化学
芳香烃受体
标识
DOI:10.1016/s0955-0674(00)00194-0
摘要
Hypoxia-inducible factor 1 (HIF-1) is an oxygen-regulated transcriptional activator that plays essential roles in mammalian development, physiology and disease pathogenesis. The HIF-1 alpha subunit is subjected to oxygen-dependent ubiquitination and proteasomal degradation that is mediated by the von Hippel-Lindau protein. Interaction of HIF-1 alpha transactivation domains with coactivators is induced by hypoxia. The signal transduction pathway remains enigmatic, but involves generation of reactive oxygen species. Nitric oxide induces HIF-1 alpha under non-hypoxic conditions but inhibits hypoxia-induced HIF-1 alpha expression.
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