细胞周期蛋白D1
细胞周期蛋白D
生物
细胞周期蛋白B
细胞周期
癌症研究
细胞周期蛋白
周期素
细胞周期蛋白
细胞生物学
细胞周期蛋白A2
细胞生长
癌症
遗传学
作者
R.M.L. Zwijsen,Rob Klompmaker,Ellen Wientjens,Petra Kristel,Bart van der Burg,Rob Michalides
标识
DOI:10.1128/mcb.16.6.2554
摘要
Cyclin D1 controls G1-associated processes, including G0-to-G1 and G1-to-S transitions. This study demonstrates a novel aspect of cyclin D1 as a regulator of the transition between G1 and G0. Overexpression of cyclin D1 in MCF7 breast tumor cells resulted in a continued proliferation under low-serum conditions, whereas nonoverexpressing cells ceased to grow. This difference in growth was due to a reduced exit from G1 to G0 in cyclin D1-overexpressing cells. Our data therefore suggest a model in which cyclin D1 overexpression in tumor cells is responsible for hyperproliferation under growth factor-deprived conditions.
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