氧化应激
微粒
化学
脂质过氧化
环境化学
柴油机排气
DNA损伤
遗传毒性
活性氧
氧化磷酸化
燃烧
生物化学
毒性
DNA
有机化学
作者
Peter Møller,Nicklas Raun Jacobsen,Janne Kjærsgaard Folkmann,Pernille Høgh Danielsen,Lone Mikkelsen,Jette Gjerke Hemmingsen,Lise K. Vesterdal,Lykke Forchhammer,Håkan Wallin,Steffen Loft
标识
DOI:10.3109/10715760903300691
摘要
Particulates are small particles of solid or liquid suspended in liquid or air. In vitro studies show that particles generate reactive oxygen species, deplete endogenous antioxidants, alter mitochondrial function and produce oxidative damage to lipids and DNA. Surface area, reactivity and chemical composition play important roles in the oxidative potential of particulates. Studies in animal models indicate that particles from combustion processes (generated by combustion of wood or diesel oil), silicate, titanium dioxide and nanoparticles (C60 fullerenes and carbon nanotubes) produce elevated levels of lipid peroxidation products and oxidatively damaged DNA. Biomonitoring studies in humans have shown associations between exposure to air pollution and wood smoke particulates and oxidative damage to DNA, deoxynucleotides and lipids measured in leukocytes, plasma, urine and/or exhaled breath. The results indicate that oxidative stress and elevated levels of oxidatively altered biomolecules are important intermediate endpoints that may be useful markers in hazard characterization of particulates.
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