餐后
医学
内科学
氧化应激
内分泌学
糖尿病
2型糖尿病
硝基酪氨酸
安慰剂
交叉研究
胰岛素
一氧化氮
病理
替代医学
一氧化氮合酶
作者
Antonio Ceriello,Ludovica Piconi,Lisa Quagliaro,Yan Wang,Catherine A. Schnabel,James A. Ruggles,Maurice Gloster,David Maggs,Christian Weyer
出处
期刊:Diabetes Care
[American Diabetes Association]
日期:2005-03-01
卷期号:28 (3): 632-637
被引量:69
标识
DOI:10.2337/diacare.28.3.632
摘要
OBJECTIVE—Oxidative stress has been shown to be increased in the postprandial period in patients with diabetes and has been implicated in the pathogenesis of micro- and macrovascular complications. The aim of this post hoc analysis was to assess the effects of pramlintide, an amylin analog shown to reduce postprandial glucose excursions in patients with diabetes, on markers of oxidative stress in the postprandial period. RESEARCH DESIGN AND METHODS—In a randomized, single-blind, placebo-controlled, crossover study, 18 evaluable subjects with type 1 diabetes underwent two standardized breakfast meal tests and received pramlintide or placebo in addition to their preprandial insulin. The plasma concentrations of glucose and markers of oxidative stress (nitrotyrosine, oxidized LDL [ox-LDL], and total radical-trapping antioxidant parameter [TRAP]) were measured at baseline and during the 4-h postprandial period. RESULTS—Compared with placebo, pramlintide treatment significantly reduced postprandial excursions of glucose, nitrotyrosine, and ox-LDL and prevented a decline in TRAP (P < 0.03 for all comparisons). Correlation analyses adjusted for treatment revealed a significant association between postprandial mean incremental area under the curve from 0 to 4 h (AUC0–4 h) for glucose and postprandial mean incremental AUC0–4 h for each measure of oxidative stress (r = 0.75, 0.54, and −0.63 for nitrotyrosine, ox-LDL, and TRAP, respectively; P < 0.001 for all correlations). CONCLUSIONS—These findings indicate that the postprandial glucose-lowering effect of pramlintide in type 1 diabetes is associated with a significant reduction in postprandial oxidative stress.
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