医学
IgG4相关疾病
病理
腮腺
生发中心
自身免疫性胰腺炎
渗透(HVAC)
淋巴系统
腺淋巴瘤
结核(地质)
抗体
疾病
B细胞
免疫学
古生物学
物理
热力学
生物
作者
Mitsuharu Aga,Satoru Kondo,Kazunori Yamada,Seiko Sawada-Kitamura,Sayaka Yagi-Nakanishi,Kazuhira Endo,Naohiro Wakisaka,Shigeyuki Murono,Mitsuhiro Kawano,Tomokazu Yoshizaki
标识
DOI:10.1016/j.anl.2012.11.005
摘要
Immunoglobulin G4-related disease (IgG4-RD) is an inflammatory condition associated with elevated serum IgG4 levels and tissue infiltration by IgG4-expressing plasma cells. Several inflammatory conditions associated with IgG4-RD have been reported. Warthin's tumor is a benign parotid gland tumor consisting of oncocytic epithelial cells and lymphoid stroma containing lymphoid follicles with reactive germinal centers. This is the first report describing a case of Warthin's tumor with possible involvement of IgG4-RD. The patient was a 71-year-old man presenting with swollen right parotid and bilateral submandibular glands. He had a history of a Warthin's tumor of the left parotid gland, autoimmune pancreatitis, and an inflammatory abdominal aortic aneurysm. Laboratory tests revealed a high serum IgG4 level. Histological examination of the resected parotid gland showed a Warthin's tumor and a nodule showing severe lymphocytic infiltration containing many IgG4-positive plasma cells. This case shows the possible involvement of Warthin's tumor with IgG4-RD.
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