受体
抗体
人巨细胞病毒
免疫球蛋白Fc片段
巨细胞病毒
免疫球蛋白G
生物
分子生物学
细胞表面受体
碎片结晶区
WI-38
细胞
Fc受体
倍性
细胞生物学
免疫学
化学
病毒学
病毒
生物化学
疱疹病毒科
基因
病毒性疾病
作者
Jürgen Frey,Birgitt Einsfelder
出处
期刊:European journal of biochemistry
[Wiley]
日期:1984-01-01
卷期号:138 (1): 213-216
被引量:23
标识
DOI:10.1111/j.1432-1033.1984.tb07903.x
摘要
Binding studies on diploid human fibroblasts with human immunoglobulin G (IgG) demonstrate the existence of a specific receptor for this class of immunoglobulin. The receptor preferentially binds aggregated human IgG and recognizes these complexes via the Fc portion of the molecule. Cytomegalovirus infection of diploid human fibroblasts results in a more than 100‐fold increase in the number of IgG‐receptors present on the cell surface. The binding of aggregated IgG by these newly expressed receptors exhibits the characteristics of the binding mediated by the receptors detectable in uninfected cells.
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