机械转化
生物
整合素
细胞生物学
细胞外基质
肌动蛋白细胞骨架
细胞骨架
细胞粘附
焦点粘着
肌动蛋白
信号转导
细胞粘附分子
神经科学
细胞
遗传学
作者
Tyler D. Ross,Brian Bg Coon,Sanguk Yun,Nicolas Baeyens,Keiichiro Tanaka,Mingxing Ouyang,Martin A. Schwartz
标识
DOI:10.1016/j.ceb.2013.05.006
摘要
Forces acting on cells govern many important regulatory events during development, normal physiology, and disease processes. Integrin-mediated adhesions, which transmit forces between the extracellular matrix and the actin cytoskeleton, play a central role in transducing effects of forces to regulate cell functions. Recent work has led to major insights into the molecular mechanisms by which these adhesions respond to forces to control cellular signaling pathways. We briefly summarize effects of forces on organs, tissues, and cells; and then discuss recent advances toward understanding molecular mechanisms.
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