T细胞受体
磷酸化
受体
细胞生物学
配体(生物化学)
化学
生物
分子生物学
T细胞
生物化学
免疫学
免疫系统
作者
Ellen N. Kersh,Andréy S. Shaw,Paul M. Allen
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1998-07-24
卷期号:281 (5376): 572-575
被引量:328
标识
DOI:10.1126/science.281.5376.572
摘要
The T cell receptor (TCR) alphabeta heterodimer interacts with its ligands with high specificity, but surprisingly low affinity. The role of the zeta component of the murine TCR in contributing to the fidelity of antigen recognition was examined. With sequence-specific phosphotyrosine antibodies, it was found that zeta undergoes a series of ordered phosphorylation events upon TCR engagement. Completion of phosphorylation steps is dependent on the nature of the TCR ligand. Thus, the phosphorylation steps establish thresholds for T cell activation. This study documents the sophisticated molecular events that follow the engagement of a low-affinity receptor.
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