Do Nonsteroidal Antiinflammatory Drugs Reduce the Risk of Alzheimer's Disease?

In this issue of the Journal, in 't Veld and colleagues1 report the results of a long-term prospective study of the relation between the use of nonsteroidal antiinflammatory drugs (NSAIDs) and the onset of Alzheimer's disease. This important article appears to resolve puzzling conflicts among the results of prior studies of the possible neuroprotective effects of NSAIDs.The dementia of Alzheimer's disease has an insidious onset and a gradually progressive course. Although the pathogenesis of the disease remains controversial, the process is widely thought to begin in midlife or earlier, decades before the appearance of symptoms. At that point, largely . . .