Suberosols A−D, Four New Sesquiterpenes with β-Caryophyllene Skeletons from a Taiwanese Gorgonian Coral Subergorgia suberosa

Four new β-caryophyllene-derived sesquiterpenes alcohols, suberosols A (1), B (2), C (3), and D (4), along with two known β-caryophyllene-derived sesqueterpene ketones, buddledins C (5) and D (6), were isolated from a Taiwanese gorgonian coral Subergorgia suberosa. The structures of 1−4 were determined on the basis of extensive spectroscopic analyses. Cytotoxicity of these compounds toward various cancer cell lines is also described.