A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer

(Cell Metabolism 30, 1107–1119.e1–e8; December 3, 2019) As a result of an author oversight in the originally published version of this article, the example image of H&E staining for the HKB99 group was accidentally sourced from a lung section of mice harboring HCC827-Luc, instead of HCC827ER9-Luc, when Figure 6F was assembled. This error does not affect any results or conclusions of the paper. The authors sincerely apologize for any confusion and inconvenience that the oversight may have caused. A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung CancerHuang et al.Cell MetabolismOctober 10, 2019In BriefPGAM1 plays a critical role in cancer cell metabolism. Huang et al. discovered a novel PGAM1 inhibitor HKB99, which allosterically blocks the structure of PGAM1, impacting both its catalytic activity and ACTA2 interaction. HKB99 significantly inhibits NSCLC tumor growth and metastasis in vivo by impacting both PGAM1’s metabolic activity and nonmetabolic function. Full-Text PDF Open Archive