Microbiome Engineering for Metabolic Disorders

There is an intricate relationship between the human microbiome and its host with the microbiome-derived metabolites playing a crucial role in the establishment and maintenance of human health. An imbalance in the composition of the gut microbiome is associated with a wide array of disease states. Herein, we discuss some of the molecular mechanisms by which the gut microbiome is linked to the development of various metabolic disorders and present examples of microbiome engineering using wild type or genetically modified probiotics that have been evaluated in preclinical models and clinical trials for their therapeutic efficacy.