Shenqi compound ameliorates type-2 diabetes mellitus by modulating the gut microbiota and metabolites

肠道菌群 代谢组学 厚壁菌 蔷薇花 2型糖尿病 拟杆菌 血糖性 化学 拟杆菌 肠道通透性 胰岛素抵抗 生物化学 糖尿病 生物 药理学 微生物学 免疫学 细菌 内分泌学 生物信息学 16S核糖体RNA 基因 遗传学
作者
Xiyu Zhang,Heting Wang,Chunguang Xie,Zhipeng Hu,Yuan Zhang,Sihan Peng,Yuchi He,Jian Kang,Hong Gao,Haipo Yuan,Ya Liu,Gang Fan
出处
期刊:Journal of Chromatography B [Elsevier BV]
卷期号:1194: 123189-123189 被引量:29
标识
DOI:10.1016/j.jchromb.2022.123189
摘要

The gut microbiota (GM) and metabolites are important factors in mediating the development of type-2 diabetes mellitus (T2DM). An imbalance in the gut microbiota and metabolites can disrupt the function of the intestinal barrier, cause changes in the permeability of the intestinal mucosa and promote the immune inflammatory response, thereby aggravating the fluctuation of blood glucose level and promoting the occurrence and development of the chronic complications of DM. Manipulating the GM and metabolites is a promising therapeutic intervention and is being studied extensively. Shenqi compound (SQC) is a traditional Chinese medicine formulation, which has been widely used to improve T2DM. Studies have demonstrated that SQC can reduce glycemic variability, alleviate the inflammatory response, etc. However, its underlying mechanism remains unknown. Therefore, in this experiment, We administered SQC to Goto-Kakizaki (GK) rats and evaluated its effect on blood glucose homeostasis and the intestinal mucosal barrier. We identified the profiles of the GM and metabolites with the aid of 16S rDNA gene sequencing and non-target metabolomics analysis. It showed that SQC intervention could reduce glycemic variability, regulate serum levels of glucagon and insulin, and improve injury to the intestinal mucosal barrier of GK rats. In the gut, the ratio of bacteria of the phyla Bacteroidetes/Firmicutes could be improved after SQC intervention. SQC also regulated the relative abundance of Prevotellaceae, Butyricimonas, Bacteroides, Blautia, Roseburia, Lactobacillus, and Rothia. We found out that expression of 40 metabolites was significantly improved after SQC intervention. Further analyses of metabolic pathways indicated that the therapeutic effect of SQC might be related predominantly to its ability to improve gluconeogenesis/glycolysis, amino acid metabolism, lipid metabolism, citrate cycle, and butanoate metabolism. These results suggest that SQC may exert a beneficial role in T2DM by modulating the GM and metabolites in different pathways.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
scugy发布了新的文献求助10
1秒前
孤岛完成签到,获得积分10
1秒前
3秒前
三秋应助123456采纳,获得10
3秒前
虎子发布了新的文献求助10
3秒前
3秒前
Kiosta完成签到,获得积分10
3秒前
DOGDAD完成签到,获得积分10
4秒前
酷波er应助卿卿采纳,获得10
4秒前
文艺的青旋完成签到 ,获得积分10
4秒前
5秒前
年轻的青柏完成签到,获得积分10
5秒前
6秒前
清脆南蕾完成签到,获得积分10
6秒前
medzhou完成签到,获得积分10
6秒前
晨曦完成签到,获得积分10
7秒前
哈哈发布了新的文献求助10
7秒前
Salvator完成签到,获得积分10
7秒前
鲨鱼辣椒完成签到,获得积分10
8秒前
今天开心吗完成签到 ,获得积分10
8秒前
8秒前
小一完成签到,获得积分10
9秒前
Kiosta发布了新的文献求助10
10秒前
lisaltp完成签到,获得积分10
10秒前
静静等待完成签到,获得积分10
10秒前
圆圆发布了新的文献求助10
11秒前
11秒前
等待蚂蚁完成签到 ,获得积分10
12秒前
脑洞疼应助ceeray23采纳,获得20
12秒前
13秒前
kehan完成签到,获得积分10
13秒前
Manchester完成签到,获得积分10
13秒前
xwl9955完成签到 ,获得积分10
13秒前
Slide完成签到 ,获得积分20
13秒前
玛卡巴卡发布了新的文献求助10
13秒前
DarrenVan完成签到,获得积分10
14秒前
大胆的钢笔完成签到,获得积分10
14秒前
江山完成签到,获得积分20
14秒前
14秒前
奈芙莲完成签到,获得积分10
14秒前
高分求助中
【请各位用户详细阅读此贴后再求助】科研通的精品贴汇总(请勿应助) 10000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
International Code of Nomenclature for algae, fungi, and plants (Madrid Code) (Regnum Vegetabile) 500
Maritime Applications of Prolonged Casualty Care: Drowning and Hypothermia on an Amphibious Warship 500
Comparison analysis of Apple face ID in iPad Pro 13” with first use of metasurfaces for diffraction vs. iPhone 16 Pro 500
Towards a $2B optical metasurfaces opportunity by 2029: a cornerstone for augmented reality, an incremental innovation for imaging (YINTR24441) 500
Materials for Green Hydrogen Production 2026-2036: Technologies, Players, Forecasts 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4061661
求助须知:如何正确求助?哪些是违规求助? 3600275
关于积分的说明 11433299
捐赠科研通 3323815
什么是DOI,文献DOI怎么找? 1827483
邀请新用户注册赠送积分活动 897954
科研通“疑难数据库(出版商)”最低求助积分说明 818774