医学
普瑞巴林
加巴喷丁
恶心
止痛药
呕吐
荟萃分析
麻醉
置信区间
外科
作者
Kuo‐Chuan Hung,Shao-Chun Wu,Min-Hsien Chiang,Chih‐Wei Hsu,Jui-Yi Chen,Ping-Wen Huang,Shao-Chun Wu
出处
期刊:Obesity Surgery
[Springer Nature]
日期:2022-05-17
卷期号:32 (8): 2734-2743
被引量:4
标识
DOI:10.1007/s11695-022-06109-6
摘要
This meta-analysis investigated the effect of oral gabapentinoids (i.e., pregabalin and gabapentin) on analgesic consumption (i.e., primary outcome) and pain relief (i.e., secondary outcome) in patients following bariatric surgery. Analysis of five eligible trials published between 2010 and 2019 including 363 participants receiving gabapentinoids revealed a significantly lower morphine consumption [mean difference (MD) = - 15.1 mg, p = 0.004; evidence certainty: low] and risk of nausea/vomiting [risk ratio (RR) = 0.49, p = 0.002; evidence certainty: high] at postoperative 6-24 h. There was also a lower pain score at postoperative 0-4 h (MD = - 1.41, p < 0.00001; evidence certainty: low) and 6-12 h (MD = - 0.9, p = 0.007; evidence certainty: low) compared with controls, while pain severity at postoperative 24 h was comparable between two groups. In summary, preoperative oral gabapentinoids optimized postoperative pain outcomes and reduced risk of nausea/vomiting following bariatric surgery.
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