微晶纤维素
材料科学
根(腹足类)
压实
极限抗拉强度
赋形剂
纤维素
休止角
复合材料
压片
化学工程
纹理(宇宙学)
微粉化
色谱法
化学
粒径
有机化学
植物
图像(数学)
人工智能
计算机科学
工程类
生物
作者
Yue Zhang,Jinzhi Li,Yating Gao,Fei Wu,Hong Yang,Lan Shen,Xiao Lin
标识
DOI:10.1016/j.ijpharm.2022.121837
摘要
It has been reported that hydrophilic nano-silica (N) markedly improved direct compaction (DC) properties of Zingiberis Rhizoma alcoholic extract. This study aims to examine the broader scope and generality of the previous work by investigating (i) three powders, i.e., the directly pulverized product, ethanol extract, and water extract prepared from the same medicinal herb-Puerariae Lobatae Radix (named DP, EE, and WE) and (ii) the effects on their DC properties of co-processing with N, hydrophobic nano-silica (BN), or microcrystalline cellulose (C). Unexpectedly, C provided the best improvement on tabletability for WE, while N for both DP and EE. More importantly, only N could move all parent powders to a regime suitable for DC, and BN rather than C enabled parent WE to be directly compressed. Typically, 6/9 N-modified powders simultaneously met the requirements of DC on bulk density, flowability, and tablet tensile strength (σt). Principal component analysis indicated that DC properties were mainly governed by flowability and texture properties. The partial least-squares regression model revealed that flowability, texture parameters, and deformation behavior of powders were dominating factors impacting tablet σt and solid fraction. Overall, the findings are promising for the manufacture of high drug loading tablets of herbs by DC.
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