淋巴瘤
转移
弥漫性大B细胞淋巴瘤
癌症研究
上皮-间质转换
间充质干细胞
病态的
细胞外基质
癌症转移
疾病
癌症
医学
生物
病理
内科学
细胞生物学
作者
Yingying Chen,Lingling Jiang,Lixia Liu,Min Ruan,Zhicheng Zhou,Mingzhen Yang,Leiming Xia
标识
DOI:10.2174/1389557522666220519085134
摘要
Diffuse Large B-cell Lymphoma (DLBCL), an aggressive cancer of the B cells, is the most common pathological type of Non-hodgkin's Lymphoma (NHL), and the typical heterogeneity of the disease is due to metastasis, which indicates a poor prognosis. Currently, the key mechanism of metastasis remains largely unknown, and research focus on the same in DLBCL. Recent studies have focused on the role of Mesenchymal-epithelial Transition (MET) and Epithelial- mesenchymal Transition (EMT), the Extracellular Matrix (ECM), chemokines, cancer stem cells, and non-coding RNAs in DLBCL. Here, we have summarised the advances and challenges in the investigation of metastasis in DLBCL and attempted to reveal the potential targets that can improve patient survival.
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