上睑下垂
坏死性下垂
水痘带状疱疹病毒
生物
程序性细胞死亡
背景(考古学)
病毒
免疫系统
病毒学
先天免疫系统
细胞凋亡
细胞生物学
免疫学
遗传学
古生物学
作者
Megan Steain,Barry Slobedman,Allison Abendroth
出处
期刊:Current Topics in Microbiology and Immunology
日期:2021-01-01
卷期号:: 59-73
被引量:1
摘要
Like other herpesviruses, varicella-zoster virus (VZV) evolved a wide range of functions to modulate a broad array of host defences, presumably as a means to provide a survival advantage to the virus during infection. In addition to control of components of the adaptive immune response, VZV also modulates a range of innate responses. In this context, it has become increasingly apparent that VZV encodes specific functions that interfere with programmed cell death (PCD) pathways. This review will overview the current understanding of VZV-mediated control of PCD pathways, focussing on the three most well-defined PCD pathways: apoptosis, necroptosis and pyroptosis. We will also discuss future directions about these PCD pathways that are yet to be explored in the context of VZV infection.
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