前额叶皮质
抗焦虑药
表观遗传学
神经科学
焦虑
机制(生物学)
心理学
医学
生物
认知
精神科
基因
遗传学
认识论
哲学
作者
Yan Lu,Ji‐an Wei,Fengzhen Yang,Mei Wang,Siqi Wang,Tao Cheng,Xuanjun Liu,Yanbin Jia,Kwok–Fai So,Li Zhang
标识
DOI:10.1002/advs.202105731
摘要
Physical exercise is effective in alleviating mental disorders by improving synaptic transmission; however, the link between body endurance training and neural adaptation has not yet been completely resolved. In this study, the authors investigated the role of RNA N6 -methyladenosine (m6A), an emerging epigenetic mechanism, in improved resilience against chronic restraint stress. A combination of molecular, behavioral, and in vivo recording data demonstrates exercise-mediated restoration of m6A in the mouse medial prefrontal cortex, whose activity is potentiated to exert anxiolytic effects. Furthermore, it is revealed that hepatic biosynthesis of one methyl donor is necessary for exercise to improve brain RNA m6A to counteract environmental stress. This novel liver-brain axis provides an explanation for brain network changes upon exercise training and provides new insights into the diagnosis and treatment of anxiety disorders.
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