去细胞化
角膜
材料科学
细胞外基质
自愈水凝胶
生物医学工程
组织工程
眼科
细胞生物学
医学
生物
高分子化学
作者
Ghasem Yazdanpanah,Xiang Shen,Tara Nguyen,Khandaker N. Anwar,Oju Jeon,Yuanfei Jiang,Mohammad Pachenari,Yayue Pan,Tolou Shokuhfar,Mark I. Rosenblatt,Eben Alsberg,Ali R. Djalilian
标识
DOI:10.1002/adfm.202113383
摘要
Corneal injuries are a major cause of blindness worldwide. To restore corneal integrity and clarity, there is a need for regenerative bio-integrating materials for in-situ repair and replacement of corneal tissue. Here, we introduce Light-curable COrnea Matrix (LC-COMatrix), a tunable material derived from decellularized porcine cornea extracellular matrix containing un-denatured collagen and sulfated glycosaminoglycans. It is a functionalized hydrogel with proper swelling behavior, biodegradation, and viscosity that can be cross-linked in situ with visible light, providing significantly enhanced biomechanical strength, stability, and adhesiveness. Cross-linked LC-COMatrix strongly adheres to human corneas ex vivo and effectively closes full-thickness corneal perforations with tissue loss. Likewise, in vivo, LC-COMatrix seals large corneal perforations, replaces partial-corneal stromal defects and bio-integrates into the tissue in rabbit models. LC-COMatrix is a natural ready-to-apply bio-integrating adhesive that is representative of native corneal matrix with potential applications in corneal and ocular surgeries.
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