糖苷
化学
多重耐药
立体化学
传统医学
水解
生物
生物化学
医学
抗生素
作者
Ludi Zhang,Lin Yuefang,Min Huang,Wenbo Chen,Lixin Duan,Zhongqiu Liu,Linlin Lu,Rongrong Zhang
出处
期刊:Phytochemistry
[Elsevier]
日期:2022-07-01
卷期号:199: 113172-113172
被引量:2
标识
DOI:10.1016/j.phytochem.2022.113172
摘要
Six unidentified C21 steroidal glycosides, cynwallosides A-F, as well as twenty-two known compounds, were isolated from the roots of Cynanchum wallichii Wight. The structures of cynwallosides A-F were determined by spectroscopic analysis and acidic hydrolysis. Most of these twenty-eight compounds were found to significantly reverse drug resistance in both the MCF-7/ADR and HepG2/ADM cell lines by suppressing P-gp protein expression. Further investigation revealed that three compounds suppressed P-gp expression by significantly inactivating the JNK and NF-κB pathways.
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