The incidence of depression in the world has been rising in recent years, with the characteristics of high recurrence rate, high disability rate, and high suicide rate. The Global Burden of Disease Survey shows that according to disability-adjusted life years, depression has the largest weight in the burden of mental illness, about 40.5% [1]. It is estimated that by 2030, depression will become the top burden of disease in the world. An epidemiological survey by Huang Yueqin. ect [2] et al. showed that the lifetime prevalence of depression was 6.8%. The cause of depression is still unclear, which brings great difficulties and challenges to precision medicine.