芳香烃受体
Wnt信号通路
Notch信号通路
淀粉样前体蛋白
海马体
细胞生物学
信号转导
海马结构
β淀粉样蛋白
化学
生物
内科学
内分泌学
转录因子
生物化学
阿尔茨海默病
医学
基因
疾病
肽
作者
Majid Keshavarzi,Fatemeh Moradbeygi,Keivan Mobini,Ali Ghaffarian Bahraman,Parisa Mohammadi,Afsaneh Ghaedi,Afshin Mohammadi-Bardbori
出处
期刊:Toxicology Research
[Oxford University Press]
日期:2021-12-29
卷期号:11 (1): 147-161
被引量:1
标识
DOI:10.1093/toxres/tfab120
摘要
The amyloid beta precursor protein (APP) plays a pathophysiological role in the development of Alzheimer's disease as well as a physiological role in neuronal growth and synaptogenesis. The aryl hydrocarbon receptor (AhR)/WNT/Catenin Beta 1 (CTNNB1)/Notch signaling pathways stamp in many functions, including development and growth of neurons. However, the regulatory role of AhR-/WNT-/CTNNB1-/Notch-induced APP expression and its influence on hippocampal-dependent learning and memory deficits is not clear. Male BALB/C mice received 6-formylindolo[3,2-b]carbazole (an AhR agonist), CH223191(an AhR antagonist), DAPT (an inhibitor of Notch signaling), and XAV-939 (a WNT pathway inhibitor) at a single dose of 100 μg/kg, 1, 5 , and 5 mg/kg of body weight, respectively, via intraperitoneal injection alone or in combination. Gene expression analyses and protein assay were performed on the 7th and 29th days. To assess the hippocampal-dependent memory, all six mice also underwent contextual fear conditioning on the 28th day after treatments. Our results showed that endogenous ligand of AhR has a regulatory effect on APP gene. Also, the interaction of AhR/WNT/CTNNB1 has a positive regulatory effect, but Notch has a negative regulatory effect on the mRNA and protein expression of APP, which have a correlation with mice's learning skills and memory.
科研通智能强力驱动
Strongly Powered by AbleSci AI