组胺
肥大细胞
免疫球蛋白E
化学
肿瘤坏死因子α
药理学
化合物48/80
佛波
过敏反应
过敏
分泌物
免疫学
抗体
生物化学
生物
脱颗粒
受体
信号转导
蛋白激酶C
作者
Sang‐Yong Kim,Choi Yong-Gil,Sang‐Hyun Kim,Hye‐Young Shin,Moon‐Kyu Ahn,Hyung‐Min Kim,Tae‐Yong Shin
标识
DOI:10.1081/iph-120037725
摘要
The effect of aqueous extract of Isodon japonicus Hara (Labiatae) (IJAE) on mast cell-mediated immediate-type allergic reactions was investigated. IJAE inhibited systemic allergic reaction induced by compound 48/80. When IJAE was pretreated at the same concentrations with systemic allergic reaction test, the plasma histamine levels were reduced in a dose-dependent manner. IJAE also inhibited local allergic reaction activated by anti-dinitrophenyl (DNP) IgE antibody. IJAE dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. IJAE inhibited the secretion of tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187-stimulated human mast cell line (HMC-1) cells. In addition, the expression of TNF-alpha mRNA in HMC-1 cells was inhibited by IJAE. These results indicate that IJAE may be beneficial in the regulation of immediate-type allergic reaction.
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