PEDF公司
干细胞
细胞生物学
间充质干细胞
生物
神经干细胞
神经发生
血管生成
癌症研究
多能干细胞
免疫学
祖细胞
作者
Philip Fitchev,Chuhan Chung,Beth A. Plunkett,Charles B. Brendler,Susan E. Crawford
出处
期刊:Current Drug Delivery
[Bentham Science]
日期:2014-09-22
卷期号:11 (5): 552-560
被引量:3
标识
DOI:10.2174/156720181105140922122754
摘要
Anti-angiogenic pigment epithelium-derived factor (PEDF) is a multifunctional 50kD secreted glycoprotein emerging as a key factor in stem cell renewal. Characteristics of the stem cell niche can be highly dependent on location, access to the vasculature, oxygen tension and neighboring cells. In the neural stem cell (NSC) niche, specifically the subventricular zone, PEDF actively participates in the self renewal process and promotes stemness by upregulating Notch signaling effectors Hes1 and Hes5. The local vascular endothelial cells and ependymal cells are the likely sources of PEDF for the NSC while mesenchymal and retinal stem cells can actually produce PEDF. The opposing actions of PEDF and VEGF on various cells are recapitulated in the NSC niche. Intraventricular injection of PEDF promotes stem cell renewal, while injection of VEGF prompts differentiation and neurogenesis in the subventricular zone. Enhancing the expression of PEDF in stem cells has promising therapeutic implications. Bone marrow mesenchymal stem cells overexpressing PEDF effectively inhibited pathologic angiogenesis in the murine eye and these same cells suppressed hepatocellular carcinoma growth. As a protein with bioactivities in nearly all normal organ systems, it is likely that PEDF will continue to gain visibility as an essential component in the development and delivery of novel stem cell-based therapies to combat disease. Keywords: Bone marrow, mesenchymal, neural, renewal, vascular.
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