索拉非尼
纳米载体
生物相容性
化学
细胞毒性
生物相容性材料
MTT法
LNCaP公司
三嗪
体外
药物输送
共价键
核化学
生物物理学
癌细胞
生物化学
癌症研究
生物医学工程
癌症
高分子化学
有机化学
医学
生物
内科学
肝细胞癌
作者
Nazanin Mokhtari,Somayeh Taymouri,Mina Mirian,Mohammad Dinari
标识
DOI:10.1016/j.molliq.2019.111898
摘要
In the present study, a novel polyimine-based covalent triazine framework (PI-CTF) was introduced as a promising biocompatible carrier for sorafenib (SFN) delivery. High specific surface area and porosity allowed us to achieve drug loading and encapsulation efficiency as high as 83% and 98%, respectively. The in vitro drug release study of SFN-loaded PI-CTF showed a sustained and pH-dependent release behavior in which acidic pH accelerated drug release compared with the neutral pH. Notably, cytotoxicity assay against L929 cells revealed the safety and biocompatibility of PI-CTF. Moreover, MTT assay against LNCaP prostate cancer cells expressed that the anticancer activity of SFN had no diminution after incorporating into PI-CTF. Thus, PI-CTF has envisaged as a great promise toward anti-cancer drug carrier.
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