Effect of bronchialveolar lavage on mechanical ventilation in children with severe pneumonia

Objective To investigate the efficacy and application of bronchoalveolar lavage in children with severe pneumonia undergoing mechanical ventilation. Methods Using a prospective randomized controlled clinical study, 202 children with severe pneumonia received mechanical ventilation in Hunan Children′s Hospital from January 2016 to January 2018 were selected as the subjects.According to the digital method, all cases were divided into treatment group (101 cases) and control group (101 cases) randomly.The patients in the control group were given conventional treatment (anti-infection and symptomatic therapy). The treatment group was treated with bronchoalveolar lavage on the basis of conventional treatment.The basic situation, the respiratory function before and after the treatment, the inflammation index, the curative effect and the prognosis of two groups were analyzed. Results There were no significant differences between the two groups in gender, age, course pre-admission, pediatric critical illness score, respiratory function and inflammation index (P>0.05). The respiratory function indexes of the treatment group were obviously improved 2 hours after the treatment and the PaO2, PaO2/FiO2 and SaO2 were significantly higher than those of the control group[PaO2: (82.4±6.4) mmHg(1 mmHg=0.133 kPa) vs.(74.0±5.5) mmHg, PaO2/FiO2: (360.2±21.3) mmHg vs.(332.6±23.5) mmHg, SaO2: (94.9±8.2)% vs.(88.6±10.3)%], while the PaCO2 were significantly lower than the control group[(37.3±10.3) mmHg vs.(45.8±5.5) mmHg], and the differences were statistically significant (P 0.05]. Conclusion The bronchoalveolar lavage can improve the respiratory function, reduce the inflammatory reaction, shorten mechanical ventilation duration and PICU stay in children with severe pneumonia undergoing mechanical ventilation obviously.It is worth popularizing in the PICU because of the improvement of curative effect in these children. Key words: Mechanical ventilation; Bronchoalveolar lavage with fiberoptic bronchoscopy; Inflammatory biomarker; Severe pneumonia; Children