医学
队列
内科学
疾病
神经病理学
危险系数
痴呆
肿瘤科
生物标志物
病理
置信区间
生物化学
化学
作者
Sebastian Palmqvist,Shorena Janelidze,Yakeel T. Quiroz,Henrik Zetterberg,Francisco Lopera,Erik Stomrud,Yi Su,Yinghua Chen,Geidy E. Serrano,Antoine Leuzy,Niklas Mattsson,Olof Strandberg,Ruben Smith,Andrés Villegas,Diego Sepúlveda‐Falla,Xiyun Chai,Nicholas K. Proctor,Thomas G. Beach,Kaj Blennow,Jeffrey L. Dage
出处
期刊：JAMA
[American Medical Association]
日期：2020-07-28
卷期号：324 (8): 772-772
被引量：1466
标识
DOI：10.1001/jama.2020.12134
摘要
Among 1402 participants from 3 selected cohorts, plasma P-tau217 discriminated AD from other neurodegenerative diseases, with significantly higher accuracy than established plasma- and MRI-based biomarkers, and its performance was not significantly different from key CSF- or PET-based measures. Further research is needed to optimize the assay, validate the findings in unselected and diverse populations, and determine its potential role in clinical care.
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