肝细胞癌
乙型肝炎病毒
医学
突变体
内科学
肿瘤科
癌
乙型肝炎
肝切除术
丙型肝炎病毒
基因
病毒
切除术
癌症研究
病毒学
生物
外科
遗传学
作者
Chiao-Fang Teng,Tsai‐Chung Li,Hsi‐Yuan Huang,Jing Lin,Wenshu Chen,Woei‐Cherng Shyu,Han Chieh Wu,Cheng Yuan Peng,Ih‐Jen Su,Long‐Bin Jeng
出处
期刊:Viruses
[MDPI AG]
日期:2020-07-24
卷期号:12 (8): 796-796
被引量:23
摘要
Hepatocellular carcinoma (HCC) is among the most common and lethal human cancers worldwide. Despite curative resection, high recurrence of HCC remains a big threat, leading to poor patient outcomes. Hepatitis B virus (HBV) pre-S mutants, which harbor deletions over pre-S1 and pre-S2 gene segments of large surface proteins, have been implicated in HCC recurrence. Therefore, a reliable approach for detection of pre-S mutants is urgently needed for predicting HCC recurrence to improve patient survival. In this study, we used a next-generation sequencing (NGS)-based platform for quantitative detection of pre-S mutants in the plasma of HBV-related HCC patients and evaluated their prognostic values in HCC recurrence. We demonstrated that the presence of deletions spanning the pre-S2 gene segment and the high percentage of pre-S2 plus pre-S1 + pre-S2 deletions, either alone or in combination, was significantly and independently associated with poor recurrence-free survival and had greater prognostic performance than other clinicopathological and viral factors in predicting HCC recurrence. Our data suggest that the NGS-based quantitative detection of pre-S mutants in plasma represents a promising approach for identifying patients at high risk for HBV-related HCC recurrence after surgical resection in a noninvasive manner.
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