单核吞噬细胞系统
趋化性
光热治疗
癌症研究
外周血单个核细胞
药物输送
免疫学
医学
化学
生物
体外
纳米技术
受体
生物化学
有机化学
材料科学
作者
Min Li,Shuya Li,Han Zhou,Xinfeng Tang,Yi Wu,Wei Jiang,Zhigang Tian,Xuechang Zhou,Xianzhu Yang,Yucai Wang
标识
DOI:10.1038/s41467-020-14963-0
摘要
Abstract The efficacy of nano-mediated drug delivery has been impeded by multiple biological barriers such as the mononuclear phagocyte system (MPS), as well as vascular and interstitial barriers. To overcome the abovementioned obstacles, we report a nano-pathogenoid (NPN) system that can in situ hitchhike circulating neutrophils and supplement photothermal therapy (PTT). Cloaked with bacteria-secreted outer membrane vesicles inheriting pathogen-associated molecular patterns of native bacteria, NPNs are effectively recognized and internalized by neutrophils. The neutrophils migrate towards inflamed tumors, extravasate across the blood vessels, and penetrate through the tumors. Then NPNs are rapidly released from neutrophils in response to inflammatory stimuli and subsequently taken up by tumor cells to exert anticancer effects. Strikingly, due to the excellent targeting efficacy, cisplatin-loaded NPNs combined with PTT completely eradicate tumors in all treated mice. Such a nano-platform represents an efficient and generalizable strategy towards in situ cell hitchhiking as well as enhanced tumor targeted delivery.
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