生物
衰老
细胞生长
细胞生物学
内生
限制点
细胞衰老
细胞
细胞周期检查点
细胞周期
神经科学
细胞周期进展
遗传学
表型
生物化学
基因
作者
Lindsey R. Pack,Leighton H. Daigh,Tobias Meyer
标识
DOI:10.1016/j.ceb.2019.05.005
摘要
Precise regulation of cellular proliferation is critical to tissue homeostasis and development, but misregulation leads to diseases of excess proliferation or cell loss. To achieve precise control, cells utilize distinct mechanisms of growth arrest such as quiescence and senescence. The decision to enter these growth-arrested states or proliferate is mediated by the core cell-cycle machinery that responds to diverse external and internal signals. Recent advances have revealed the molecular underpinnings of these cell-cycle decisions, highlighting the unique nature of cell-cycle entry from quiescence, identifying endogenous DNA damage as a quiescence-inducing signal, and establishing how persistent arrest is achieved in senescence.
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