High prevalence of chronic kidney disease among patients with diabetic foot: A cross‐sectional study at a tertiary hospital in China

ABSTRACT Objective Chronic kidney disease (CKD) is a severe complication of diabetes mellitus (DM). However, the prevalence of CKD among DM patients with diabetic foot (DF) is unknown. Accordingly, we conducted a cross‐sectional study at a tertiary hospital to explore the prevalence of CKD among DF patients. Methods A total of 42 132 inpatients with DM were enrolled from May 2015 to October 2018. Four hundred and forty‐seven DF patients were selected, and 116 patients with incomplete data were excluded. CKD was defined as an estimated glomerular filtration rate < 60 mL/min per 1.73 m 2 or presence of proteinuria (urine protein ≥1). We compared the CKD prevalence of DF patients with non‐DF patients and general CKD patients hospitalized in China. Multivariable regression analysis was performed to explore the relationship between different variables in DF patients and CKD. Results A total of 361 DF patients aged 67.9 ± 12.2 years were analyzed. Of these patients, 63.7% of were males. The prevalence of CKD was 49.0% ( n = 177), which was higher than that observed for the general inpatients (4.5%, n = 871 742). However, 59.9% of CKD patients were not diagnosed during their hospitalizations. In the multivariable logistic regression analysis, after adjusting for potential confounders, the following variables were correlated with CKD: uric acid (odds ratio (OR) = 1.49, 95% confidence interval (CI) = 1.22–1.82), homocysteine (OR = 1.05, 95% CI = 1.00–1.10), and HBA1C (OR = 1.23, 95% CI = 1.04–1.47). Conclusion This study revealed that the prevalence of CKD among DF patients was high, and special attention should be paid to these patients.