催化作用
甲醇
铱
化学
化学选择性
亚甲基
组合化学
水滑石
有机化学
作者
Wenwen Qiang,Xiang Liu,Teck‐Peng Loh
出处
期刊:ACS Sustainable Chemistry & Engineering
[American Chemical Society]
日期:2019-04-10
卷期号:7 (9): 8429-8439
被引量:28
标识
DOI:10.1021/acssuschemeng.9b00094
摘要
The first example of a heterogeneous catalyst based on hydrotalcite-derived Mg–Al oxides supported iridium (Ir/MgxAlO) for activation of methanol in the synthesis of bis(indolyl)methanes (BIMs) is reported. In this clean and reusable iridium-based catalytic system, a variety of substituted indoles were selectively converted to their corresponding BIMs in moderate to good yields with high tolerance to reducible functional groups by using methanol as a bridging methylene (−CH2−) donor. The high catalytic activity and selectivity of the reaction benefit from the delicate cooperation of redox/acid–base surface sites on this artificially designed multifunctional Ir/MgxAlO catalyst. The overall simplicity, chemoselectivity and sustainability of the catalytic system make this approach a valuable and step-economical tool to construct C–C bond directly from methanol in the synthesis of more complex molecules.
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