Tumor pH and intracellular reduction responsive polypeptide nanomedicine with a sheddable PEG corona and a disulfide-cross-linked core

To overcome the tumor and cellular barriers in cancer chemotherapy, a new class of polypeptide copolymer nanoparticles with a sheddable PEG corona and a dynamic disulfide bond cross-linked core was fabricated for intracellular pHe and reduction triggered cytotoxicity.