Crossed Cerebellar Diaschisis: Diagnostic and Prognostic Value of MRI Derived Imaging—A BOLD-Cerebrovascular Reactivity, MRI Perfusion, and H2O-PET Comparison Study

Introduction: Crossed cerebellar diaschisis (CCD) refers to a reduction in cerebellar blood flow and metabolism contralateral to a supratentorial lesion and corresponds to poorer clinical outcome. It is thought to be caused by an interruption of the cortico-ponto-cerebellar or the cerebello-thalamico-cortical fiber tracts. Positron emission tomography (PET) imaging is typically used to detect CCD, but advancing noninvasive magnetic resonance imaging (MRI) techniques such as dynamic susceptibility contract (DSC), MRI-derived parameters, or blood oxygenation-level dependent (BOLD)-derived cerebrovascular reactivity (CVR) may prove be more optimal tools to characterize this disease. Hence, we aimed to study the novel diagnostic and prognostic potential of DSC-MRI and BOLD-CVR to detect CCD.