生物安全
合成生物学
风险分析(工程)
计算机科学
生物技术
计算生物学
生物
业务
作者
Jeong Wook Lee,Ching-Kit Chan,Shimyn Slomovic,James J. Collins
标识
DOI:10.1038/s41589-018-0056-x
摘要
The increasing use of engineered organisms for industrial, clinical, and environmental applications poses a growing risk of spreading hazardous biological entities into the environment. To address this biosafety issue, significant effort has been invested in creating ways to confine these organisms and transgenic materials. Emerging technologies in synthetic biology involving genetic circuit engineering, genome editing, and gene expression regulation have led to the development of novel biocontainment systems. In this perspective, we highlight recent advances in biocontainment and suggest a number of approaches for future development, which may be applied to overcome remaining challenges in safeguard implementation.
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