生物
有丝分裂
功能(生物学)
染色体分离
主轴检查点
细胞生物学
基因
计算生物学
动细胞
遗传学
染色体
作者
Spyridon T. Pachis,Geert J. P. L. Kops
出处
期刊:Open Biology
[The Royal Society]
日期:2018-08-01
卷期号:8 (8)
被引量:82
摘要
Discovered in 1991 in a screen for genes involved in spindle pole body duplication, the monopolar spindle 1 (Mps1) kinase has since claimed a central role in processes that ensure error-free chromosome segregation. As a result, Mps1 kinase activity has become an attractive candidate for pharmaceutical companies in the search for compounds that target essential cellular processes to eliminate, for example, tumour cells or pathogens. Research in recent decades has offered many insights into the molecular function of Mps1 and its regulation. In this review, we integrate the latest knowledge regarding the regulation of Mps1 activity and its spatio-temporal distribution, highlight gaps in our understanding of these processes and propose future research avenues to address them.
科研通智能强力驱动
Strongly Powered by AbleSci AI