小RNA
自闭症
生物
表观遗传学
组蛋白
遗传学
生物信息学
DNA甲基化
计算生物学
基因
精神科
基因表达
医学
作者
Hamid M. Abdolmaleky,Jin‐Rong Zhou,Sam Thiagalingam
出处
期刊:Epigenomics
[Future Medicine]
日期:2021-08-01
卷期号:13 (15): 1231-1245
被引量:4
标识
DOI:10.2217/epi-2021-0074
摘要
During the last two decades, diverse epigenetic modifications including DNA methylation, histone modifications, RNA editing and miRNA dysregulation have been associated with psychiatric disorders. A few years ago, in a review we outlined the most common epigenetic alterations in major psychiatric disorders (e.g., aberrant DNA methylation of DTNBP1, HTR2A, RELN, MB-COMT and PPP3CC, and increased expression of miR-34a and miR-181b). Recent follow-up studies have uncovered other DNA methylation aberrations affecting several genes in mental disorders, in addition to dysregulation of many miRNAs. Here, we provide an update on new epigenetic findings and highlight potential origin of the diversity and inconsistencies, focusing on drug effects, tissue/cell specificity of epigenetic landscape and discuss shortcomings of the current diagnostic criteria in mental disorders.
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