A review on biological and medicinal significance of thiazoles

Thiazole, a five-membered heterocyclic compound constitutes the skeleton of various commercially marketed drug candidates and the heart-core in a diverse range of entities of biological and medicinal interest. It is a versatile and essential component of natural products and medicinally significant heterocyclic compounds. The chemistry of thiazoles was widely developed in terms of anti-microbial, anti-cancer, anti-tubercular, anti-oxidant, anti-inflammatory, and other therapeutically active agents after the pioneering work of Hofmann and Hantzsch, Bogert and coworkers in 1887. Besides these, thiazole heterocycles are also useful as the constituents of several dyes and photographic materials. The present review encompasses and highlights the recent progress in the development of thiazole based heterocyclic compounds for various applications focusing it a scaffold of biological and medicinal interest.