生物
背景(考古学)
癌变
可进化性
癌症
细胞周期
酶
免疫系统
癌症治疗
尿素循环
癌症研究
细胞生长
细胞生物学
计算生物学
免疫学
生物化学
遗传学
氨基酸
古生物学
精氨酸
作者
Emma Hajaj,Marco Sciacovelli,Christian Frezza,Ayelet Erez
出处
期刊:Molecular Cell
[Elsevier]
日期:2021-09-01
卷期号:81 (18): 3749-3759
被引量:34
标识
DOI:10.1016/j.molcel.2021.08.005
摘要
The expression of the urea cycle (UC) proteins is dysregulated in multiple cancers, providing metabolic benefits to tumor survival, proliferation, and growth. Here, we review the main changes described in the expression of UC enzymes and metabolites in different cancers at various stages and suggest that these changes are dynamic and should hence be viewed in a context-specific manner. Understanding the evolvability in the activity of the UC pathway in cancer has implications for cancer-immune cell interactions and for cancer diagnosis and therapy.
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