Selenium supplementation and oxidative stress: A review

Oxidative stress is defined as an imbalance between the production of oxidants (free radicals or reactive oxygen species) and their eradication by protective mechanisms, such as antioxidants (vitamin C, vitamin E, b-carotene, selenium and methionine). Increased oxidative stress is associated with metabolic risk factors and may contribute to the development of several obesity-related comorbidities, including insulin resistance, type 2 diabetes, nonalcoholic fatty liver disease, and atherosclerosis. The present review aimed to evaluate the effects of selenium supplementation on oxidative stress biomarkers. We have searched PubMed, Scopus, ISI web of science, Embase and the Cochrane library databases were searched to evaluate the clinical efficacy. We detected 14 studies that evaluated the effect of selenium supplementation on oxidative stress biomarkers n adults. Several studies have shown that Supplementation with selenium significantly reduce Malondialdehyde levels and increase Glutathione and total antioxidant capacity levels.