断奶
地穴
抗生素
生物
金霉素
微生物学
抗生素耐药性
肠道菌群
基础(医学)
生物利用度
食品科学
动物科学
男科
免疫学
生物技术
内分泌学
药理学
医学
胰岛素
作者
Hui Han,Shunfen Zhang,Ruqing Zhong,Chaohua Tang,Jie Yin,Junmin Zhang,Hongfu Zhang
摘要
Weaning stress can cause serious damage to piglet's health. Chlortetracycline (CTC) is widely used to ameliorate weaning stress and prevent infectious diseases in weaned piglets. However, antibiotics as growth promoters have to be limited because of increased antimicrobial resistance. In this study, we evaluated the effects of CTC on growth performance and intestinal functions in order to provide evidence for seeking antibiotic substitutes in weaned piglets.A total of 20 weaned piglets were fed a basal diet or a diet supplemented with 75 mg/kg CTC. CTC decreased the crypt depth and increased the ratio of villus height to crypt depth, whilst failing to affect growth performance and serum biochemical parameters and cytokines. 16S rRNA sequencing suggested that CTC supplementation had no effect on the diversity and composition of colonic microbiota.We speculated that gut microbiota is no longer sensitive to a low concentration of CTC due to the long-term use and low bioavailability of CTC in weaned piglets.
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