免疫学
鼻息肉
医学
呼吸道
慢性鼻-鼻窦炎
哮喘
特发性肺纤维化
肺
炎症
呼吸道感染
呼吸系统
内科学
作者
Tengyu Chen,Min Zhou,Man-qing Lin,Shuting Liang,Yan Yan,S. M. Wang,Caishan Fang,Dan Li,Yan Ruan
出处
期刊:International Archives of Allergy and Immunology
[S. Karger AG]
日期:2021-01-01
卷期号:182 (11): 1097-1102
被引量:18
摘要
SERPINE1 protein is one important member of the serine proteinase inhibitor E superfamily that plays a crucial role in the fibrinolytic system. It has been identified which is related to chronic inflammatory lung diseases like allergic asthma and lung fibrosis. Recently, researchers have focused on the impact of SERPINE1 and its genetic polymorphisms on inflammatory diseases of the upper respiratory tract. In this review, we conclude that SERPINE1 is widely involved in the pathological process of chronic rhinosinusitis and allergic rhinitis (AR) and may play a pivotal role in tissue remodelling in chronic rhinosinusitis without nasal polyps. It is also found that the 4G allele of SERPINE1 gene is associated with the risk of upper respiratory diseases. More studies are needed to further clarify how SERPINE1 influences chronic rhinosinusitis and AR, which would be conducive to improving the therapeutic efficacy of treatments for upper respiratory diseases.
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