糖酵解
癌症研究
瓦博格效应
转录因子
生物
细胞生物学
小RNA
癌症
厌氧糖酵解
癌变
生物化学
新陈代谢
基因
遗传学
作者
Ling Li,Yingchun Liang,Kang Liu,Yang Liu,Shan Gao,Siyu Chen,Ying Li,Wenye You,Qian Dong,Hong Tian,Yan Zhang,Shuai Jin,Tao Wang,Wei Zhao,Haixing Mai,Jun Huang,Xiao Han,Quanbo Ji,Qi Song,Chao Yang,Shixin Zhao,Xiaowei Xu,Qinong Ye
出处
期刊:Cancer Cell
[Elsevier]
日期:2018-03-01
卷期号:33 (3): 368-385.e7
被引量:265
标识
DOI:10.1016/j.ccell.2018.01.010
摘要
Aerobic glycolysis (the Warburg effect) facilitates tumor growth, and drugs targeting aerobic glycolysis are being developed. However, how the Warburg effect is directly regulated is largely unknown. Here we show that transcription factor SIX1 directly increases the expression of many glycolytic genes, promoting the Warburg effect and tumor growth in vitro and in vivo. SIX1 regulates glycolysis through HBO1 and AIB1 histone acetyltransferases. Cancer-related SIX1 mutation increases its ability to promote aerobic glycolysis and tumor growth. SIX1 glycolytic function is directly repressed by microRNA-548a-3p, which is downregulated, inversely correlates with SIX1, and is a good predictor of prognosis in breast cancer patients. Thus, the microRNA-548a-3p/SIX1 axis strongly links aerobic glycolysis to carcinogenesis and may become a promising cancer therapeutic target.
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