番红花苷
脂质过氧化
线粒体
氧化应激
线粒体毒性
化学
药理学
线粒体内膜
毒性
生物化学
细胞色素c
活性氧
细胞生物学
生物
有机化学
作者
Bahareh Sadat Yousefsani,Jalal Pourahmad,Hossein Hosseinzadeh
标识
DOI:10.1080/15376516.2017.1368054
摘要
In this study, we want to understand whether crocin could prevent mitochondrial damage caused by As III. For this purpose, we determined different mitochondrial toxicity endpoints caused by As III. We evaluated mitochondrial ROS formation, lipid peroxidation, mitochondrial membrane potential (MMP) collapse, mitochondrial outer membrane integrity and cytochrome c release. Our results showed that pretreatment with crocin at a concentration of 25 µg/ml significantly (p < 0.001) reduced As III-induced mitochondrial ROS formation, lipid peroxidation, MMP collapse and mitochondrial swelling. Crocin also protected the mitochondria by decreasing the mitochondrial outer membrane damage that leads to reduce the amount of cytochrome c release. These results demonstrated that crocin is a promising antidotal candidate by ameliorating As III-induced oxidative stress through mitochondrial targeting.
科研通智能强力驱动
Strongly Powered by AbleSci AI