催化作用
化学
氧化磷酸化
组合化学
甲烷氧化偶联
小学(天文学)
金属
反应条件
有机化学
生物化学
天文
物理
作者
Gabriela Freitas Pereira de Souza,Theodora Von Zuben,Airton G. Salles
出处
期刊:ACS Sustainable Chemistry & Engineering
[American Chemical Society]
日期:2017-08-22
卷期号:5 (9): 8439-8446
被引量:25
标识
DOI:10.1021/acssuschemeng.7b02353
摘要
A simple route toward the selective synthesis of imines and amides through oxidative coupling–oxidative amidation of amines using widely available NaOCl is presented. Under this approach, unprecedented one-pot synthesis of symmetrical and unsymmetrical secondary amides from primary amines as a single starting material is reported. This metal-catalyst-free protocol relies upon “on water” acceleration to obtain the desired products in high yields. An additive-based robustness screen was conducted to demonstrate the high reaction tolerance to several chemical motifs. Furthermore, mechanistic studies support a proposed pathway for the targeted oxidation products.
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