Nutritional trace elements influence the pathogenesis and resolution of inflammatory bowel disease

.) have shown great potential as novel therapeutic strategies. They effectively alleviate colitis in preclinical models by enhancing targeting, improving bioavailability, and synergistically exerting antioxidant and anti-inflammatory effects. However, current research is mostly limited to the preclinical stage, and its clinical translation faces challenges such as optimal dosages, long-term safety, interactions between elements, and individual differences. In summary, restoring and maintaining trace element balance is a promising auxiliary strategy in the management of IBD. Future research should focus on developing intelligent delivery systems, combining personalized nutrition and medicine, to promote the transformation of trace elements from basic nutritional support to mechanism-driven, precise auxiliary treatment, ultimately improving the long-term prognosis of IBD patients.