Highly Active Strontium Peroxide Nanoparticles Induce Alkalization/Oxidation to Potentiate Cancer Immuno-Metabolic Therapy

-mediated oxidative stress and alkalization-driven acidosis reversal. Interestingly, it has been found that lactic acid significantly amplifies the glycolytic level in macrophages and metabolically promotes SrPN-induced macrophage M1 polarization, which evokes anticancer immunity through the intratumoral metabolite leveraging. Eventually, SrPN exhibits especially high tumor inhibition efficiency in an orthotopic HCC model via clinically friendly ultrasound-guided percutaneous injection by the combined cancer cell killing and immuno-metabolic regulation of TME. This work presents an alkalization-strengthened oxidative stress-based immune-metabolic regulation strategy to potentiate the HCC immune-microenvironment for biocompatible and effective destruction.