Phytoceramide and 6-hydroxyceramide deficiency correlates with barrier function alteration in atopic dermatitis skin

Atopic dermatitis (AD) is a complex skin inflammatory disease with an increasing prevalence over the years (Ständer 2021). While the skin barrier defect has been widely recognized for its role in the pathophysiology of AD (Schmuth et al. 2024), its mechanism of action and the link with ceramides composition remain unclear.