Phytoceramide and 6-hydroxyceramide deficiency correlates with barrier function alteration in atopic dermatitis skin

Atopic dermatitis (AD) is a complex skin inflammatory disease with an increasing prevalence over the years ( Ständer 2021 10. Ständer, S. Atopic Dermatitis N. Engl. J. Med. 2021; 384 :1136-1143 http://www.nejm.org/doi/10.1056/NEJMra2023911 Crossref Scopus (320) PubMed Google Scholar ). While the skin barrier defect has been widely recognized for its role in the pathophysiology of AD ( Schmuth et al. 2024 8. Schmuth, M. ∙ Eckmann, S. ∙ Moosbrugger-Martinz, V. ... Skin Barrier in Atopic Dermatitis J. Invest. Dermatol. 2024; 144 :989-1000 Full Text Full Text (PDF) Scopus (73) PubMed Google Scholar ), its mechanism of action and the link with ceramides composition remain unclear.