医学
糖尿病
GPX4
脂质过氧化
程序性细胞死亡
疾病
自噬
氧化应激
细胞凋亡
活性氧
2型糖尿病
生物信息学
死因
细胞生物学
内科学
内分泌学
生物
生物化学
过氧化氢酶
谷胱甘肽过氧化物酶
作者
Qian Deng,Yue Zhu,Mengmeng Zhang,Aihua Fei,Jiaqi Liang,Jinjin Zheng,Qingping Zhang,Tong Cheng,Xia Ge
摘要
Diabetes is a complex metabolic disease. In recent years, diabetes and its chronic complications have become a health hotspot of global concern. It is very important to find promising therapeutic targets and directions. Ferroptosis is a new type of programmed cell death that is different from cell necrosis, apoptosis, and autophagy. Ferroptosis is mainly characterized by iron-dependent lipid peroxidation. With the reduction of the anti-oxidative capacity of cells, the accumulated reactive lipid oxygen species will cause oxidative cell death and lead to ferroptosis at lethal levels. Recent studies have shown that ferroptosis plays an important regulatory role in the initiation and development of diabetes, as well as various complications of diabetes. In this review, we will summarize new findings related to ferroptosis and diabetic complications and propose ferroptosis as a potential target for treating diabetic complications.
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