封锁
免疫系统
癌症研究
免疫检查点
免疫原性
化学
氧化还原
平衡
腺癌
PD-L1
胰腺癌
双重角色
细胞凋亡
胰腺导管腺癌
线粒体
对偶(语法数字)
免疫
免疫疗法
医学
平衡(能力)
癌症
作者
Ziheng Chen,I-Lin Ho,Jintan Liu,Melinda Soeung,Er-Yen Yen,Sara Sainani,Charles A. Dyke,Rutvi Shah,Hyuk Jean Kwon,Guangchun Han,Xinmiao Yan,Shaojun Zhang,Sanjana Srinivasan,Johnathon L. Rose,Francesca Citron,Shan Jiang,Qing Chang,Ningping Feng,Giannicola Genovese,Sisi Gao
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2025-12-02
卷期号:86 (5): 1132-1147
标识
DOI:10.1158/0008-5472.can-24-4211
摘要
GFER is essential for mitochondrial redox balance and suppressing tumor immunogenicity in pancreatic tumors, with the combination of GFER inhibition with immune checkpoint blockade resulting in a strong antitumor response.
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